|INSM Overview
INSM

INSMED Inc

Healthcare • CIK: 0001104506

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Market Cap
$34.64B
P/E (TTM)
-27.2x
Rev Growth (TTM)
+66.7%
Net Margin (TTM)
-210.5%
FCF Yield (TTM)
-2.8%
FCF Margin (TTM)
-159.6%

LATEST EARNINGS

Q4 FY2025
14 days ago
View source
Revenue
$263.84B
+153.0%
Net Income
$-328.49B
EPS
$-1.54
  • ARIKAYCE global revenue grew 19% in 2025 compared to 2024, exceeding the upper end of 2025 guidance.
  • BRINSUPRI U.S. commercial launch exceeded expectations, contributing $144.6 million in Q4 2025 and $172.7 million for full-year 2025.
  • Total company revenues reached $606.4 million for full-year 2025, a 67% increase year-over-year.
  • Company ends 2025 with approximately $1.4 billion of cash, cash equivalents, and marketable securities.

Cash Flow Health

Free Cash Flow0/8 positive
TTM$-968M
Q4 '25
$-264M-19%
Q3 '25
$-222M-6%
FCF Margin
TTM-159.6%
Q4 '25-100.1%+36%
Sector: 0.0%Below Avg
OCF Margin-154.2%
OCF/NI0.73x
CapEx Coverage-28.7x
FCF Yield-2.8%
FCF Growth (2Y)
Cash Conversion Cycle
156 days
DSO: 40+DIO: 330DPO: 214

Capital Allocation & Returns

Total Shareholder Yield
TTM0.0%
Div Yield0.0%

Insufficient data

Dividend & Payout Metrics
Dividend Yield (TTM)0.0%
Free Cash Flow (TTM)$-967.6M
Capital Return / FCF0.0%
Est. Dividends Paid (TTM)$0
Shows how management rewards shareholders

Operational Efficiency & Returns

Return on Invested CapitalTTM
-71.5%
Volatile
+0.0% YoY+15.4%
P25MedianP75
25th pctl (med: 0.0%)
DuPont BreakdownROIC = Margin × Turn × (1+D/E)
NOPAT Margin
-206.4%
8Q: -243.8%
Asset Turnover
0.28x
8Q: 0.22x
Leverage (1+D/E)
1.73x
D/E: 0.73x
DuPont: -98.7%-71.5% ROIC
Asset & CapEx Efficiency
Fixed Asset Turn
6.75x
8Q:5.08x
+413.7%
Invested Cap Turn
0.35x
8Q:0.28x
+8.0%
CapEx Intensity
1.9%
8Q:2.0%
CapEx/Depreciation
3.12x
Asset-based ROIC formula

QUARTERLY TRENDS

Last 8 quarters + TTM

MetricTTMQ4 2025Q3 2025Q2 2025Q1 2025Q4 2024Q3 2024Q2 2024Q1 2024
Revenue
$606.4M
$263.8M85.4%
$142.3M32.5%
$107.4M15.7%
$92.8M11.1%
$104.4M11.8%
$93.4M3.4%
$90.3M19.7%
$75.5M
Operating Income
$-1.2B
$-319.7M12.6%
$-366.0M17.0%
$-312.9M26.1%
$-248.1M7.7%
$-230.4M8.0%
$-213.4M26.1%
$-288.9M98.6%
$-145.5M
Net Income
$-1.3B
$-328.5M11.2%
$-370.0M15.0%
$-321.7M25.4%
$-256.6M8.9%
$-235.5M6.8%
$-220.5M26.6%
$-300.6M91.4%
$-157.1M
Operating Cash Flow
$-935.0M
$-247.6M12.7%
$-219.8M6.9%
$-205.6M21.6%
$-262.1M33.7%
$-196.0M8.3%
$-180.9M47.1%
$-123.0M33.2%
$-184.0M
Free Cash Flow
$-967.6M
$-264.2M18.9%
$-222.2M6.3%
$-209.1M23.2%
$-272.2M34.2%
$-202.8M9.8%
$-184.6M42.3%
$-129.7M31.3%
$-188.7M
Total Equity
N/A

Valuation Analysis

Fair Value
Price-to-EarningsTTM
-27.2x
Volatile
8Q: -55.6x-7180%
Valuation Lenses
Earnings
-27.2x
vs sector
Cash Flow
-35.0x
EV/FCF vs
Growth-Adj
PEG
N/A
Quality-Adj
P/E per %ROIC
ROIC: -71.5%
Shareholder Returns
Dividend
Buyback
Total Yield
Market Cap$34.64B
EV$33.85B
Multi-angle valuation analysis with sector context

Business Quality & Moat

Overall Quality Score
-231/100
Below Average

Composite score: Returns (40%) + Consistency (30%) + Earnings Quality (30%)

Returns on Capital

Return on Equity (ROE)Top 10%
-1.8%
8Q:
Return on Invested Capital (ROIC)Below Avg
-71.5%
8Q:
+15.4%

DuPont Analysis (ROIC = NOPAT Margin × Asset Turnover)

NOPAT Margin: -206.4%
Asset Turnover: 0.28x

Earnings Quality

Cash Conversion

0.73x

OCF / Net Income

FCF Consistency

Positive quarters

Competitive Moat Indicators

Pricing Power

Gross Margin79.7%

Capital Efficiency

Invested Capital Turnover0.35x

Working Capital

Cash Conversion Cycle156 days

Growth Quality & Momentum

Moderate Growth
Growth Quality Score
70/100
Growth 40%
Margins 30%
FCF 20%
Consistency 10%

Growth Rates

Revenue Growth YoY
66.7%
OpInc Growth YoY
-38.8%
EPS Growth YoY
-14.9%
FCF 3Y CAGR
N/A

Margin Quality & Sustainability

Moderate
Profitability Cascade
Gross
79.7%
Operating
-205.6%
Top 25% in sector
Net
-210.5%
Margins Unknown
Earnings Quality Signals
SBC / Revenue
FCF vs Net Gap
+51.0 pts
FCF: -159.6% | Net: -210.5%

Quality = stability + cash conversion + low dilution

Balance Sheet & Solvency

Fortress
Net Debt / EBITDA
Net Cash
(0.0x)Net Cash: $889.08M
Interest Coverage
+Net cash position: $889.08M
Leverage Metrics
Debt-to-Equity
0.73x
Balance sheet risk & solvency analysis